A method for approximating optimal statistical significances with machine-learned likelihoods Ernesto Arganda, Xabier Marcano, Víctor Martín Lozano, Anibal D. Medina, Andres D. Perez, Manuel Szewc and Alejandro Szynkman Eur. Phys. J. C, 82 11 (2022) 993 Published online: 05 November 2022 DOI: 10.1140/epjc/s10052-022-10944-3