Protein packing defects “heat up” interfacial water María Belén Sierra, Sebastián R. Accordino, J. Ariel Rodriguez-Fris, Marcela A. Morini, Gustavo A. Appignanesi and Ariel Fernández Stigliano Eur. Phys. J. E, 36 6 (2013) 62 Published online: 25 June 2013 DOI: 10.1140/epje/i2013-13062-7